When designing a web site, a typical user screen size/resolution should be considered.
Designing for smaller screen (now-days, probably 800×600pix) will make the life of people with smaller screens easier, but penalise those with larger monitors.
There is a difference between computer screen size, and inner browser window size. As browser menus, and scroll bars take part of the screen estate.
The resource I have always used is Sizing Up the Browsers. This is quite an old page, but the information is still valid.
Recently I have come across this article: Actual Browser Sizes which is more up-to-date, and goes into more details, taking into consideration that some users might not use a full window size for a browser.